Lens crystallins. Innovation associated with changes in gene regulation.
نویسنده
چکیده
منابع مشابه
Gene sharing, lens crystallins and speculations on an eye/ear evolutionary relationship.
The crystallins comprise 80-90% of the water-soluble proteins of the transparent, cellular, refractive eye lens and are responsible for its optical properties. Comparative studies have established that the crystallins are surprisingly diverse and often differ among species in a taxon-specific fashion. In general, the crystallins are derived from or identical to metabolic enzymes or stress (smal...
متن کاملRegulation of gene expression by Pax6 in ocular cells: a case of tissue-preferred expression of crystallins in lens.
Lens development is an excellent model for genetic and biochemical studies of embryonic induction, cell cycle regulation, cellular differentiation and signal transduction. Differentiation of lens is characterized by lens-preferred expression and accumulation of water-soluble proteins, crystallins. Crystallins are required for light transparency, refraction and maintenance of lens integrity. Her...
متن کاملEvolutionary Origins of Pax6 Control of Crystallin Genes
The birth of novel genes, including their cell-specific transcriptional control, is a major source of evolutionary innovation. The lens-preferred proteins, crystallins (vertebrates: α- and β/γ-crystallins), provide a gateway to study eye evolution. Diversity of crystallins was thought to originate from convergent evolution through multiple, independent formation of Pax6/PaxB-binding sites withi...
متن کاملSusceptibility of ovine lens crystallins to proteolytic cleavage during formation of hereditary cataract.
PURPOSE To produce two-dimensional electrophoresis (2-DE) maps for ovine crystallins and examine changes in ovine crystallins during cataract formation. METHODS Soluble and insoluble fractions were isolated from normal, whole lenses of 26-week-old sheep, the proteins separated by 2-DE, and the spots digested with trypsin and subjected to tandem mass spectral analysis. Spot identifications wer...
متن کاملGenetics of crystallins: cataract and beyond.
The crystallins were discovered more than 100 years ago by Mörner (1893. Untersuchungen der Proteinsubstanzen in den lichtbrechenden Medien des Auges. Z. Physiol. Chem. 18, 61-106) as the main structural proteins of the vertebrate eye lens. Since that time the major mammalian crystallins referred to as alpha-, beta-, and gamma-crystallins were characterized with respect to their genetic organiz...
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عنوان ژورنال:
- The Journal of biological chemistry
دوره 267 7 شماره
صفحات -
تاریخ انتشار 1992